GPRC5B-Mediated Sphingomyelin Synthase 2 Phosphorylation Plays a Critical Role in Insulin Resistance

GPRC5B recruitment of Src family kinases has been implicated in diet-induced insulin resistance. However, the mechanism of this action is not fully understood. Here, we report that GPRC5B-mediated phosphorylation of sphingomyelin synthase 2 (SMS2) by Fyn is a crucial step in the development of insul...

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Detalles Bibliográficos
Autores principales: Kim, Yeon-Jeong, Greimel, Peter, Hirabayashi, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197706/
https://www.ncbi.nlm.nih.gov/pubmed/30343189
http://dx.doi.org/10.1016/j.isci.2018.10.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197706/
https://www.ncbi.nlm.nih.gov/pubmed/30343189
http://dx.doi.org/10.1016/j.isci.2018.10.001

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