Synergistic effect of Nutlin-3 combined with MG-132 on schwannoma cells through restoration of merlin and p53 tumour suppressors

BACKGROUND: The great majority of sporadic vestibular schwannomas (VSs) are due to the mutations of the NF2 gene encoding merlin. Sporadic VSs exhibit variable growth patterns and only a small fraction of the tumours are fast-growing; however, the underlying mechanisms remain undefined. METHODS: DNA...

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Detalles Bibliográficos
Autores principales: Chen, Hongsai, Xue, Lu, Huang, He, Wang, Hantao, Zhang, Xiaoman, Zhu, Weidong, Wang, Zhigang, Wang, Zhaoyan, Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197711/
https://www.ncbi.nlm.nih.gov/pubmed/30274821
http://dx.doi.org/10.1016/j.ebiom.2018.09.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197711/
https://www.ncbi.nlm.nih.gov/pubmed/30274821
http://dx.doi.org/10.1016/j.ebiom.2018.09.042

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