Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis

OBJECTIVE: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are significant differences in POMC processing between humans and rodents, and littl...

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Detalles Bibliográficos
Autores principales: Kirwan, Peter, Kay, Richard G., Brouwers, Bas, Herranz-Pérez, Vicente, Jura, Magdalena, Larraufie, Pierre, Jerber, Julie, Pembroke, Jason, Bartels, Theresa, White, Anne, Gribble, Fiona M., Reimann, Frank, Farooqi, I. Sadaf, O'Rahilly, Stephen, Merkle, Florian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197775/
https://www.ncbi.nlm.nih.gov/pubmed/30201275
http://dx.doi.org/10.1016/j.molmet.2018.08.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197775/
https://www.ncbi.nlm.nih.gov/pubmed/30201275
http://dx.doi.org/10.1016/j.molmet.2018.08.006

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