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Structure of the human epithelial sodium channel by cryo-electron microscopy

The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na(+) and water homeostasis. ENaCs assemble as heterotrimeric channels that harbor protease-sensitive domains critical for gating the channel. Here, we present the structure of human ENaC in the uncleaved state det...

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Detalles Bibliográficos
Autores principales:	Noreng, Sigrid, Bharadwaj, Arpita, Posert, Richard, Yoshioka, Craig, Baconguis, Isabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197857/ https://www.ncbi.nlm.nih.gov/pubmed/30251954 http://dx.doi.org/10.7554/eLife.39340

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