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Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections
Fragment-based drug discovery (FBDD) is a well-established approach for the discovery of novel medicines, illustrated by the approval of two FBBD-derived drugs. This methodology is based on the utilization of small “fragment” molecules (<300 Da) as starting points for drug discovery and optimizat...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198038/ https://www.ncbi.nlm.nih.gov/pubmed/30386766 http://dx.doi.org/10.3389/fchem.2018.00460 |