A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells

Piplartine (piperlongumine) is a plant-derived compound found in some Piper species that became a novel potential antineoplastic agent. In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh(3))(2)]PF(6) (where, PIP-OH = piplartine deme...

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Detalles Bibliográficos
Autores principales: Oliveira, Maiara de S., Barbosa, Marília I.F., de Souza, Thiago Belarmino, Moreira, Diogo R.M., Martins, Felipe Terra, Villarreal, Wilmer, Machado, Rafael P., Doriguetto, Antônio Carlos, Soares, Milena B.P., Bezerra, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198128/
https://www.ncbi.nlm.nih.gov/pubmed/30359932
http://dx.doi.org/10.1016/j.redox.2018.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198128/
https://www.ncbi.nlm.nih.gov/pubmed/30359932
http://dx.doi.org/10.1016/j.redox.2018.10.006

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