Calcium Channel Ca(V)2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we demonstrate that leptin-induced depolarization of POMC neurons is associated with the augmentation of a voltage-gated calcium (Ca(V)) conductance with...

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Detalles Bibliográficos
Autores principales: Smith, Mark A., Katsouri, Loukia, Virtue, Samuel, Choudhury, Agharul I., Vidal-Puig, Antonio, Ashford, Michael L.J., Withers, Dominic J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198286/
https://www.ncbi.nlm.nih.gov/pubmed/30304668
http://dx.doi.org/10.1016/j.celrep.2018.09.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198286/
https://www.ncbi.nlm.nih.gov/pubmed/30304668
http://dx.doi.org/10.1016/j.celrep.2018.09.024

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