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Calcium Channel Ca(V)2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we demonstrate that leptin-induced depolarization of POMC neurons is associated with the augmentation of a voltage-gated calcium (Ca(V)) conductance with...

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Detalles Bibliográficos
Autores principales:	Smith, Mark A., Katsouri, Loukia, Virtue, Samuel, Choudhury, Agharul I., Vidal-Puig, Antonio, Ashford, Michael L.J., Withers, Dominic J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198286/ https://www.ncbi.nlm.nih.gov/pubmed/30304668 http://dx.doi.org/10.1016/j.celrep.2018.09.024

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