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Paternal germ line aging: DNA methylation age prediction from human sperm

BACKGROUND: The relationship between aging and epigenetic profiles has been highlighted in many recent studies. Models using somatic cell methylomes to predict age have been successfully constructed. However, gamete aging is quite distinct and as such age prediction using sperm methylomes is ineffec...

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Detalles Bibliográficos
Autores principales: Jenkins, Timothy G., Aston, Kenneth I., Cairns, Bradley, Smith, Andrew, Carrell, Douglas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198359/
https://www.ncbi.nlm.nih.gov/pubmed/30348084
http://dx.doi.org/10.1186/s12864-018-5153-4