Switching Between Bicyclic and Linear Peptides — The Sulfhydryl-Specific Linker TPSMB Enables Reversible Cyclization of Peptides

Phage display-selected bicyclic peptides have already shown their great potential for the development as bioactive modulators of therapeutic targets. They can provide enhanced proteolytic stability and improved membrane permeability. Molecular design of new linker molecules has led to a variety of n...

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Detalles Bibliográficos
Autores principales: Ernst, Christoph, Heidrich, Johannes, Sessler, Catharina, Sindlinger, Julia, Schwarzer, Dirk, Koch, Pierre, Boeckler, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198510/
https://www.ncbi.nlm.nih.gov/pubmed/30386769
http://dx.doi.org/10.3389/fchem.2018.00484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198510/
https://www.ncbi.nlm.nih.gov/pubmed/30386769
http://dx.doi.org/10.3389/fchem.2018.00484

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