Combining probabilistic alignments with read pair information improves accuracy of split-alignments

MOTIVATION: Split-alignments provide base-pair-resolution evidence of genomic rearrangements. In practice, they are found by first computing high-scoring local alignments, parts of which are then combined into a split-alignment. This approach is challenging when aligning a short read to a large and...

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Detalles Bibliográficos
Autores principales: Shrestha, Anish M S, Yoshikawa, Naruki, Asai, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198854/
https://www.ncbi.nlm.nih.gov/pubmed/29790902
http://dx.doi.org/10.1093/bioinformatics/bty398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198854/
https://www.ncbi.nlm.nih.gov/pubmed/29790902
http://dx.doi.org/10.1093/bioinformatics/bty398

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