Cargando…

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

Although numerous genetic loci have been associated with coronary artery disease (CAD) with genome wide association studies, efforts are needed to identify the causal genes in these loci and link them into fundamental signaling pathways. Recent studies have investigated the disease mechanism of CAD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iyer, Dharini, Zhao, Quanyi, Wirka, Robert, Naravane, Ameay, Nguyen, Trieu, Liu, Boxiang, Nagao, Manabu, Cheng, Paul, Miller, Clint L., Kim, Juyong Brian, Pjanic, Milos, Quertermous, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198989/ https://www.ncbi.nlm.nih.gov/pubmed/30307970 http://dx.doi.org/10.1371/journal.pgen.1007681

Ejemplares similares

Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping
por: Zhao, Quanyi, et al.
Publicado: (2020)

TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression
por: Zhao, Quanyi, et al.
Publicado: (2019)

Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque
por: Cheng, Paul, et al.
Publicado: (2022)

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells
por: Kim, Juyong Brian, et al.
Publicado: (2017)

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
por: Wirka, Robert C., et al.
Publicado: (2019)

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap
por: Nurnberg, Sylvia T., et al.
Publicado: (2015)

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci
por: Sazonova, Olga, et al.
Publicado: (2015)

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus
por: Nanda, Vivek, et al.
Publicado: (2018)

Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
por: Nurnberg, S.T., et al.
Publicado: (2015)

Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN)
por: Naravane, Ameay V., et al.
Publicado: (2021)

Aggressive Posterior Retinopathy of Prematurity: Long-Term Outcomes Following Intravitreal Bevacizumab
por: Naravane, Ameay V., et al.
Publicado: (2022)

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
por: Miller, Clint L., et al.
Publicado: (2016)

Opposing Effects of Tcf3 and Tcf1 Control Wnt-Stimulation of Embryonic Stem Cell Self Renewal
por: Yi, Fei, et al.
Publicado: (2011)

Vitreoretinopathy-Associated Pediatric Retinal Detachment Treatment Outcomes: IRIS® Registry (Intelligent Research in Sight) Analysis
por: Belin, Peter J., et al.
Publicado: (2023)

Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases
por: Nurnberg, Sylvia T., et al.
Publicado: (2020)

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application
por: Sinha, Sanjay, et al.
Publicado: (2014)

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus
por: Miller, Clint L., et al.
Publicado: (2013)

Drosophila Smad2 Opposes Mad Signaling during Wing Vein Development
por: Sander, Veronika, et al.
Publicado: (2010)

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in T(H)17 differentiation
por: Yoon, Jeong-Hwan, et al.
Publicado: (2015)

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus
por: Donnarumma, Tiziano, et al.
Publicado: (2016)

Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation
por: Miller, Clint L., et al.
Publicado: (2014)

The role of polycarbonate monomer bisphenol-A in insulin resistance
por: Pjanic, Milos
Publicado: (2017)

Co-occurrence of frameshift mutations in SMAD6 and TCF12 in a child with complex craniosynostosis
por: Timberlake, Andrew T., et al.
Publicado: (2018)

Opposing Roles of Tcf7/Lef1 and Tcf7l2 in Cyclin D2 and Bmp4 Expression and Cardiomyocyte Cell Cycle Control during Late Heart Development
por: Ye, Bo, et al.
Publicado: (2019)

Molecular mechanisms of coronary artery disease risk at the PDGFD locus
por: Kim, Hyun-Jung, et al.
Publicado: (2023)

Molecular mechanisms of coronary artery disease risk at the PDGFD locus
por: Kim, Hyun-Jung, et al.
Publicado: (2023)

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury
por: Gallina, Alessandro L., et al.
Publicado: (2021)

Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation
por: Castillejo-Lopez, Casimiro, et al.
Publicado: (2019)

CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
por: Cook, Naomi L., et al.
Publicado: (2019)

Disease from opposing forces in regulatory control
por: Frank, Steven A
Publicado: (2023)

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells
por: Iyer, Dharini, et al.
Publicado: (2015)

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells
por: Iyer, Dharini, et al.
Publicado: (2016)

Short term visual and structural outcomes of anti-vascular endothelial growth factor (anti-VEGF) treatment delay during the first COVID-19 wave: A pilot study
por: Naravane, Ameay V., et al.
Publicado: (2021)

Chromatin Remodeling Pathways in Smooth Muscle Cell Differentiation, and Evidence for an Integral Role for p300
por: Spin, Joshua M., et al.
Publicado: (2010)

TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
por: Wang, Jing, et al.
Publicado: (2022)

ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout
por: Matsuo, Hirotaka, et al.
Publicado: (2015)

Opposing Effects of PI3K/Akt and Smad-Dependent Signaling Pathways in NAG-1-Induced Glioblastoma Cell Apoptosis
por: Zhang, Zhiguo, et al.
Publicado: (2014)

The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis
por: Huang, Wei-Juan, et al.
Publicado: (2020)

The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases
por: Mishra, Sonakshi, et al.
Publicado: (2019)

The Origin of Disease, Especially of Disease Resulting from Intrinsic as Opposed to Extrinsic Causes
por: Muir, Robert
Publicado: (1898)

Cannot write session to /tmp/vufind_sessions/sess_tgv5t5dhui1gm3s88obngsidlv