Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

Persistent hyperactivity of the Hippo effector YAP in activated satellite cells is sufficient to cause embryonal rhabdomyosarcoma (ERMS) in mice. In humans, YAP is abundant and nuclear in the majority of ERMS cases, and high YAP expression is associated with poor survival. However, YAP1 is rarely mu...

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Detalles Bibliográficos
Autores principales: Mohamed, Abdalla D., Shah, Nupur, Hettmer, Simone, Vargesson, Neil, Wackerhage, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199242/
https://www.ncbi.nlm.nih.gov/pubmed/30353028
http://dx.doi.org/10.1038/s41598-018-33852-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199242/
https://www.ncbi.nlm.nih.gov/pubmed/30353028
http://dx.doi.org/10.1038/s41598-018-33852-7

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