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Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N

Hypothalamic inflammation is thought to contribute to obesity. One potential mechanism is via gut microbiota derived bacterial lipopolysaccharide (LPS) entering into the circulation and activation of Toll-like receptor-4. This is called metabolic endotoxemia. Another potential mechanism is systemic...

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Detalles Bibliográficos
Autores principales: Dalby, Matthew J., Aviello, Gabriella, Ross, Alexander W., Walker, Alan W., Barrett, Perry, Morgan, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199263/
https://www.ncbi.nlm.nih.gov/pubmed/30353127
http://dx.doi.org/10.1038/s41598-018-33928-4