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Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases
Treatment options for Ankylosing Spondylitis (AS) are still limited. The T helper cell 17 (Th17) pathway has emerged as a major driver of disease pathogenesis and a good treatment target. Janus kinases (JAK) are key transducers of cytokine signals in Th17 cells and therefore promising targets for th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199284/ https://www.ncbi.nlm.nih.gov/pubmed/30353145 http://dx.doi.org/10.1038/s41598-018-34026-1 |