Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases

Treatment options for Ankylosing Spondylitis (AS) are still limited. The T helper cell 17 (Th17) pathway has emerged as a major driver of disease pathogenesis and a good treatment target. Janus kinases (JAK) are key transducers of cytokine signals in Th17 cells and therefore promising targets for th...

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Detalles Bibliográficos
Autores principales: Hammitzsch, Ariane, Chen, Liye, de Wit, Jelle, Al-Mossawi, M. Hussein, Ridley, Anna, Sekine, Takuya, Simone, Davide, Doig, Karen, Skapenko, Alla, Bowness, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199284/
https://www.ncbi.nlm.nih.gov/pubmed/30353145
http://dx.doi.org/10.1038/s41598-018-34026-1

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