A therapeutic approach to pantothenate kinase associated neurodegeneration

Pantothenate kinase (PANK) is a metabolic enzyme that regulates cellular coenzyme A (CoA) levels. There are three human PANK genes, and inactivating mutations in PANK2 lead to pantothenate kinase associated neurodegeneration (PKAN). Here we performed a library screen followed by chemical optimizatio...

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Detalles Bibliográficos
Autores principales: Sharma, Lalit Kumar, Subramanian, Chitra, Yun, Mi-Kyung, Frank, Matthew W., White, Stephen W., Rock, Charles O., Lee, Richard E., Jackowski, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199309/
https://www.ncbi.nlm.nih.gov/pubmed/30352999
http://dx.doi.org/10.1038/s41467-018-06703-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199309/
https://www.ncbi.nlm.nih.gov/pubmed/30352999
http://dx.doi.org/10.1038/s41467-018-06703-2

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