Defective transcription elongation in a subset of cancers confers immunotherapy resistance

The nature and role of global transcriptional deregulations in cancers are not fully understood. We report that a large proportion of cancers have widespread defects in mRNA transcription elongation (TE). Cancers with TE defects (TE(deff)) display spurious transcription and defective mRNA processing...

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Detalles Bibliográficos
Autores principales: Modur, Vishnu, Singh, Navneet, Mohanty, Vakul, Chung, Eunah, Muhammad, Belal, Choi, Kwangmin, Chen, Xiaoting, Chetal, Kashish, Ratner, Nancy, Salomonis, Nathan, Weirauch, Matthew T., Waltz, Susan, Huang, Gang, Privette-Vinnedge, Lisa, Park, Joo-Seop, Janssen, Edith M., Komurov, Kakajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199328/
https://www.ncbi.nlm.nih.gov/pubmed/30353012
http://dx.doi.org/10.1038/s41467-018-06810-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199328/
https://www.ncbi.nlm.nih.gov/pubmed/30353012
http://dx.doi.org/10.1038/s41467-018-06810-0

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