Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

TDP-43 is the major disease protein associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-TDP). Here we identify the transcriptional elongation factor Ell—a shared component of little elongation complex (LEC) and super elongatio...

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Detalles Bibliográficos
Autores principales: Chung, Chia-Yu, Berson, Amit, Kennerdell, Jason R., Sartoris, Ashley, Unger, Travis, Porta, Sílvia, Kim, Hyung-Jun, Smith, Edwin R., Shilatifard, Ali, Van Deerlin, Vivianna, Lee, Virginia M.-Y., Chen-Plotkin, Alice, Bonini, Nancy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199344/
https://www.ncbi.nlm.nih.gov/pubmed/30353006
http://dx.doi.org/10.1038/s41467-018-06543-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199344/
https://www.ncbi.nlm.nih.gov/pubmed/30353006
http://dx.doi.org/10.1038/s41467-018-06543-0

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