A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action

BACKGROUND: Epilepsy affects around 1% of people, but existing antiepileptic drugs (AEDs) only offer symptomatic relief and are ineffective in approximately 30% of patients. Hence, new AEDs are sorely needed. However, a major bottleneck is the low-throughput nature of early-stage AED screens in conv...

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Detalles Bibliográficos
Autores principales: Wong, Shi Quan, Jones, Alistair, Dodd, Steven, Grimes, Douglas, Barclay, Jeff W., Marson, Anthony G., Cunliffe, Vincent T., Burgoyne, Robert D., Sills, Graeme J., Morgan, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200019/
https://www.ncbi.nlm.nih.gov/pubmed/30189284
http://dx.doi.org/10.1016/j.jneumeth.2018.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200019/
https://www.ncbi.nlm.nih.gov/pubmed/30189284
http://dx.doi.org/10.1016/j.jneumeth.2018.09.004

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