Discovery of a CLN7 model of Batten disease in non-human primates

We have identified a natural Japanese macaque model of the childhood neurodegenerative disorder neuronal ceroid lipofuscinosis, commonly known as Batten Disease, caused by a homozygous frameshift mutation in the CLN7 gene (CLN7(−/−)). Affected macaques display progressive neurological deficits inclu...

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Detalles Bibliográficos
Autores principales: McBride, Jodi L., Neuringer, Martha, Ferguson, Betsy, Kohama, Steven G., Tagge, Ian J., Zweig, Robert C., Renner, Laurie M., McGill, Trevor J., Stoddard, Jonathan, Peterson, Samuel, Su, Weiping, Sherman, Larry S., Domire, Jacqueline S., Ducore, Rebecca M., Colgin, Lois M., Lewis, Anne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200145/
https://www.ncbi.nlm.nih.gov/pubmed/30048804
http://dx.doi.org/10.1016/j.nbd.2018.07.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200145/
https://www.ncbi.nlm.nih.gov/pubmed/30048804
http://dx.doi.org/10.1016/j.nbd.2018.07.013

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