MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective

The Fragile X-related disorders (FXDs) are Repeat Expansion Diseases resulting from an expansion of a CGG-repeat tract at the 5’ end of the FMR1 gene. The mechanism responsible for this unusual mutation is not fully understood. We have previously shown that mismatch repair (MMR) complexes, MSH2/MSH3...

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Detalles Bibliográficos
Autores principales: Zhao, Xiaonan, Zhang, Yongwei, Wilkins, Kenneth, Edelmann, Winfried, Usdin, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200270/
https://www.ncbi.nlm.nih.gov/pubmed/30312299
http://dx.doi.org/10.1371/journal.pgen.1007719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200270/
https://www.ncbi.nlm.nih.gov/pubmed/30312299
http://dx.doi.org/10.1371/journal.pgen.1007719

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