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Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling

Programmed cell death-1 (PD-1) is an inhibitory immune checkpoint receptor that negatively regulates the functioning of T cell. Although the direct targets of PD-1 were not identified, its inhibitory action on the TCR signaling pathway was known much earlier. Recent experiments suggest that the PD-1...

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Detalles Bibliográficos
Autores principales: Arulraj, Theinmozhi, Barik, Debashis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200280/
https://www.ncbi.nlm.nih.gov/pubmed/30356330
http://dx.doi.org/10.1371/journal.pone.0206232