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Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling
Programmed cell death-1 (PD-1) is an inhibitory immune checkpoint receptor that negatively regulates the functioning of T cell. Although the direct targets of PD-1 were not identified, its inhibitory action on the TCR signaling pathway was known much earlier. Recent experiments suggest that the PD-1...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200280/ https://www.ncbi.nlm.nih.gov/pubmed/30356330 http://dx.doi.org/10.1371/journal.pone.0206232 |