Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension

BACKGROUND/AIMS: Our previous studies demonstrated that intrinsic aortic smooth muscle cell (VSMC) stiffening plays a pivotal role in aortic stiffening in aging and hypertension. However, the underlying molecular mechanisms remain largely unknown. We here hypothesized that Rho kinase (ROCK) acts as...

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Detalles Bibliográficos
Autores principales: Zhou, Ning, Lee, Jia-Jye, Stoll, Shaunrick, Ma, Ben, Costa, Kevin D., Qiu, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200323/
https://www.ncbi.nlm.nih.gov/pubmed/29169155
http://dx.doi.org/10.1159/000485284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200323/
https://www.ncbi.nlm.nih.gov/pubmed/29169155
http://dx.doi.org/10.1159/000485284

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