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Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension

BACKGROUND/AIMS: Our previous studies demonstrated that intrinsic aortic smooth muscle cell (VSMC) stiffening plays a pivotal role in aortic stiffening in aging and hypertension. However, the underlying molecular mechanisms remain largely unknown. We here hypothesized that Rho kinase (ROCK) acts as...

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Detalles Bibliográficos
Autores principales:	Zhou, Ning, Lee, Jia-Jye, Stoll, Shaunrick, Ma, Ben, Costa, Kevin D., Qiu, Hongyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200323/ https://www.ncbi.nlm.nih.gov/pubmed/29169155 http://dx.doi.org/10.1159/000485284

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