Minimal PAM specificity of a highly similar SpCas9 ortholog

RNA-guided DNA endonucleases of the CRISPR-Cas system are widely used for genome engineering and thus have numerous applications in a wide variety of fields. CRISPR endonucleases, however, require a specific protospacer adjacent motif (PAM) flanking the target site, thus constraining their targetabl...

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Detalles Bibliográficos
Autores principales: Chatterjee, Pranam, Jakimo, Noah, Jacobson, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200363/
https://www.ncbi.nlm.nih.gov/pubmed/30397647
http://dx.doi.org/10.1126/sciadv.aau0766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200363/
https://www.ncbi.nlm.nih.gov/pubmed/30397647
http://dx.doi.org/10.1126/sciadv.aau0766

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