Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistance in NSCLC

Anticancer drug resistance is a major challenge of cancer therapy. We found that irinotecan-resistant NSCLC cells showed increased mitochondrial oxidative phosphorylation compared to the drug sensitive NSCLC cells. Previously, we found that combined inhibition of aldehyde dehydrogenase using gossypo...

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Detalles Bibliográficos
Autores principales: Lee, Soohyun, Lee, Jae-Seon, Seo, Jinho, Lee, Seon-Hyeong, Kang, Joon Hee, Song, Jaewhan, Kim, Soo-Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200737/
https://www.ncbi.nlm.nih.gov/pubmed/30356107
http://dx.doi.org/10.1038/s41598-018-33667-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200737/
https://www.ncbi.nlm.nih.gov/pubmed/30356107
http://dx.doi.org/10.1038/s41598-018-33667-6

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