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Argonaute2 attenuates active transcription by limiting RNA Polymerase II elongation in Drosophila melanogaster

Increasing lines of evidence support that Argonaute2 (AGO2) harbors several nuclear functions in metazoa. In particular, Drosophila AGO2 modulates transcription of developmentally regulated genes; however, the molecular mechanisms behind AGO2 recruitment into chromatin and its function in transcript...

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Detalles Bibliográficos
Autores principales: Nazer, Ezequiel, Dale, Ryan K., Palmer, Cameron, Lei, Elissa P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200757/
https://www.ncbi.nlm.nih.gov/pubmed/30356106
http://dx.doi.org/10.1038/s41598-018-34115-1