Cargando…

Aptamer-enabled uptake of small molecule ligands

The relative ease of isolating aptamers with high specificity for target molecules suggests that molecular recognition may be common in the folds of natural RNAs. We show here that, when expressed in cells, aptamers can increase the intracellular concentrations of their small molecule ligands. We ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Auwardt, Supipi Liyamali, Seo, Yeon-Jung, Ilgu, Muslum, Ray, Judhajeet, Feldges, Robert R., Shubham, Shambhavi, Bendickson, Lee, Levine, Howard A., Nilsen-Hamilton, Marit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200808/ https://www.ncbi.nlm.nih.gov/pubmed/30356136 http://dx.doi.org/10.1038/s41598-018-33887-w

Ejemplares similares

Ligands with polyfluorophenyl moieties promote a local structural rearrangement in the Spinach2 and Broccoli aptamers that increases ligand affinities
por: Anisuzzaman, Sharif, et al.
Publicado: (2022)

Live-cell imaging of Pol II promoter activity to monitor gene expression with RNA IMAGEtag reporters
por: Shin, Ilchung, et al.
Publicado: (2014)

Aptamer Applications in Neuroscience
por: Ozturk, Meric, et al.
Publicado: (2021)

Common Secondary and Tertiary Structural Features of Aptamer–Ligand Interaction Shared by RNA Aptamers with Different Primary Sequences
por: Ilgu, Muslum, et al.
Publicado: (2019)

Computational Modeling of RNA Aptamers: Structure Prediction of the Apo State
por: Yan, Shuting, et al.
Publicado: (2022)

An adaptable pentaloop defines a robust neomycin-B RNA aptamer with conditional ligand-bound structures
por: Ilgu, Muslum, et al.
Publicado: (2014)

Sampling Performance of Multiple Independent Molecular Dynamics Simulations of an RNA Aptamer
por: Yan, Shuting, et al.
Publicado: (2020)

Aptamers Targeting Membrane Proteins for Sensor and Diagnostic Applications
por: Kara, Nilufer, et al.
Publicado: (2023)

A 2′FY-RNA Motif Defines an Aptamer for Ebolavirus Secreted Protein
por: Shubham, Shambhavi, et al.
Publicado: (2018)

The Lipocalin2 Gene is Regulated in Mammary Epithelial Cells by NFκB and C/EBP In Response to Mycoplasma
por: Zhao, Wei, et al.
Publicado: (2020)

Structurally Different Yet Functionally Similar: Aptamers Specific for the Ebola Virus Soluble Glycoprotein and GP1,2 and Their Application in Electrochemical Sensing
por: Banerjee, Soma, et al.
Publicado: (2023)

RNA aptamer capture of macromolecular complexes for mass spectrometry analysis
por: Ray, Judhajeet, et al.
Publicado: (2020)

A model system for antiviral siRNA therapeutics using exosome-based delivery
por: Wallen, Margaret, et al.
Publicado: (2022)

A model system for antiviral siRNA therapeutics using exosome-based delivery
por: Wallen, Margaret, et al.
Publicado: (2022)

Aptamers: Uptake mechanisms and intracellular applications()
por: Yoon, Sorah, et al.
Publicado: (2018)

G-Quadruplex Aptamer-Ligand Characterization
por: Moreira, David, et al.
Publicado: (2022)

A mathematical model for the onset of avascular tumor growth in response to the loss of p53 function
por: Levine, Howard A., et al.
Publicado: (2007)

Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications
por: Guan, Baozhang, et al.
Publicado: (2020)

Heterometallic bond activation enabled by unsymmetrical ligand scaffolds: bridging the opposites
por: Govindarajan, R., et al.
Publicado: (2022)

Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer
por: Ptacek, Jakub, et al.
Publicado: (2020)

Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing
por: Brown, Jonathan M., et al.
Publicado: (2019)

Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
por: Liu, Mengping, et al.
Publicado: (2022)

Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides
por: Ray, Roslyn M, et al.
Publicado: (2021)

Aptamers: Active Targeting Ligands for Cancer Diagnosis and Therapy
por: Wu, Xu, et al.
Publicado: (2015)

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters
por: Ilgü, Hüseyin, et al.
Publicado: (2018)

Ligand binding by the tandem glycine riboswitch depends on aptamer dimerization but not double ligand occupancy
por: Ruff, Karen M., et al.
Publicado: (2014)

Discovery of Aptamer Ligands for Hepatic Stellate Cells Using SELEX
por: Chen, Zhijin, et al.
Publicado: (2017)

Aptamers as Smart Ligands for Targeted Drug Delivery in Cancer Therapy
por: Wei, Zongyi, et al.
Publicado: (2022)

Modulation of Aptamer–Ligand-Binding by Complementary Oligonucleotides: A G-Quadruplex Anti-Ochratoxin A Aptamer Case Study
por: Samokhvalov, Alexey V., et al.
Publicado: (2022)

Pulsed transistor operation enables miniaturization of electrochemical aptamer-based sensors
por: Bidinger, Sophia L., et al.
Publicado: (2022)

Robotic assisted generation of 2′-deoxy-2′-fluoro-modifed RNA aptamers – High performance enabling strategies in aptamer selection
por: Breuers, Stefan, et al.
Publicado: (2019)

Development of RNA Aptamer and its Ligand Binding Assay on Microchip Electrophoresis
por: Ohno, Ken-ichi, et al.
Publicado: (2012)

Ligand-induced stabilization of the aptamer terminal helix in the add adenine riboswitch
por: Di Palma, Francesco, et al.
Publicado: (2013)

Fluorescence-Based Strategies to Investigate the Structure and Dynamics of Aptamer-Ligand Complexes
por: Perez-Gonzalez, Cibran, et al.
Publicado: (2016)

Selection of high affinity aptamer-ligand for dexamethasone and its electrochemical biosensor
por: Mehennaoui, Somia, et al.
Publicado: (2019)

Complementary oligonucleotides regulate induced fit ligand binding in duplexed aptamers
por: Munzar, Jeffrey D., et al.
Publicado: (2017)

Salt-mediated two-site ligand binding by the cocaine-binding aptamer
por: Neves, Miguel A.D., et al.
Publicado: (2017)

Aptamers for Targeted Drug Delivery
por: Ray, Partha, et al.
Publicado: (2010)

Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader
por: Liang, Shaolin, et al.
Publicado: (2019)

Bio-inspired aptamers decorated gold nanoparticles enable visualized detection of malathion
por: Li, Peng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4cno7r2e7ptqrrmk5vhts43tsf