The signalling conformation of the insulin receptor ectodomain

Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically relevant, high-affinity version of the rece...

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Detalles Bibliográficos
Autores principales: Weis, Felix, Menting, John G., Margetts, Mai B., Chan, Shu Jin, Xu, Yibin, Tennagels, Norbert, Wohlfart, Paulus, Langer, Thomas, Müller, Christoph W., Dreyer, Matthias K., Lawrence, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200814/
https://www.ncbi.nlm.nih.gov/pubmed/30356040
http://dx.doi.org/10.1038/s41467-018-06826-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200814/
https://www.ncbi.nlm.nih.gov/pubmed/30356040
http://dx.doi.org/10.1038/s41467-018-06826-6

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