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Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD(+)-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions
Cumulating evidence has indicated NAD(+) deficiency as a common central pathological factor of multiple diseases and aging. NAD(+) supplement is highly protective in various disease and aging models, while two key questions have remained unanswered: (1) Does extracellular NAD(+) also produce its eff...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200843/ https://www.ncbi.nlm.nih.gov/pubmed/30405351 http://dx.doi.org/10.3389/fncel.2018.00343 |