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Antibody Epitope Specificity for dsDNA Phosphate Backbone Is an Intrinsic Property of the Heavy Chain Variable Germline Gene Segment Used

Analysis of protein sequences by the informational spectrum method (ISM) enables characterization of their specificity according to encoded information represented with defined frequency (F). Our previous data showed that F(0.367) is characteristic for variable heavy chain (VH) domains (a combinatio...

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Detalles Bibliográficos
Autores principales: Srdic-Rajic, Tatjana, Kohler, Heinz, Jurisic, Vladimir, Metlas, Radmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200867/
https://www.ncbi.nlm.nih.gov/pubmed/30405605
http://dx.doi.org/10.3389/fimmu.2018.02378