Role of the immunosuppressive microenvironment in immunotherapy

Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of t...

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Detalles Bibliográficos
Autores principales: Tormoen, Garth W., Crittenden, Marka R., Gough, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Immunotherapy and Radiation Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200899/
https://www.ncbi.nlm.nih.gov/pubmed/30370351
http://dx.doi.org/10.1016/j.adro.2018.08.018
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author Tormoen, Garth W.
Crittenden, Marka R.
Gough, Michael J.
author_facet Tormoen, Garth W.
Crittenden, Marka R.
Gough, Michael J.
author_sort Tormoen, Garth W.
collection PubMed
description Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of tumors. Herein, we review how anti-tumor immune responses are formed and how tumors avoid immune destruction. We also outline potential therapeutic targets in the immunosuppressive tumor microenvironment to promote immune control of tumors.
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spelling pubmed-62008992018-10-26 Role of the immunosuppressive microenvironment in immunotherapy Tormoen, Garth W. Crittenden, Marka R. Gough, Michael J. Adv Radiat Oncol Immunotherapy and Radiation Oncology Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of tumors. Herein, we review how anti-tumor immune responses are formed and how tumors avoid immune destruction. We also outline potential therapeutic targets in the immunosuppressive tumor microenvironment to promote immune control of tumors. Elsevier 2018-10-23 /pmc/articles/PMC6200899/ /pubmed/30370351 http://dx.doi.org/10.1016/j.adro.2018.08.018 Text en © 2018 The Authors on behalf of the American Society for Radiation Oncology http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Immunotherapy and Radiation Oncology
Tormoen, Garth W.
Crittenden, Marka R.
Gough, Michael J.
Role of the immunosuppressive microenvironment in immunotherapy
title Role of the immunosuppressive microenvironment in immunotherapy
title_full Role of the immunosuppressive microenvironment in immunotherapy
title_fullStr Role of the immunosuppressive microenvironment in immunotherapy
title_full_unstemmed Role of the immunosuppressive microenvironment in immunotherapy
title_short Role of the immunosuppressive microenvironment in immunotherapy
title_sort role of the immunosuppressive microenvironment in immunotherapy
topic Immunotherapy and Radiation Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200899/
https://www.ncbi.nlm.nih.gov/pubmed/30370351
http://dx.doi.org/10.1016/j.adro.2018.08.018
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AT goughmichaelj roleoftheimmunosuppressivemicroenvironmentinimmunotherapy

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