Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile

The pathogenicity locus (PaLoc) of Clostridioides difficile usually comprises five genes (tcdR, tcdB, tcdE, tcdA, tcdC). While the proteins TcdA and TcdB represent the main toxins of this pathogen, TcdR and TcdC are involved in the regulation of their production. TcdE is a holin family protein, memb...

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Detalles Bibliográficos
Autores principales: Mehner-Breitfeld, Denise, Rathmann, Claudia, Riedel, Thomas, Just, Ingo, Gerhard, Ralf, Overmann, Jörg, Brüser, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200909/
https://www.ncbi.nlm.nih.gov/pubmed/30405545
http://dx.doi.org/10.3389/fmicb.2018.02446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200909/
https://www.ncbi.nlm.nih.gov/pubmed/30405545
http://dx.doi.org/10.3389/fmicb.2018.02446

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