Impact of the Myosin Modulator Mavacamten on Force Generation and Cross‐Bridge Behavior in a Murine Model of Hypercontractility

BACKGROUND: Recent studies suggest that mavacamten (Myk461), a small myosin‐binding molecule, decreases hypercontractility in myocardium expressing hypertrophic cardiomyopathy‐causing missense mutations in myosin heavy chain. However, the predominant feature of most mutations in cardiac myosin bindi...

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Detalles Bibliográficos
Autores principales: Mamidi, Ranganath, Li, Jiayang, Doh, Chang Yoon, Verma, Sujeet, Stelzer, Julian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201428/
https://www.ncbi.nlm.nih.gov/pubmed/30371160
http://dx.doi.org/10.1161/JAHA.118.009627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201428/
https://www.ncbi.nlm.nih.gov/pubmed/30371160
http://dx.doi.org/10.1161/JAHA.118.009627

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