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In silico model-guided identification of transcriptional regulator targets for efficient strain design
BACKGROUND: Cellular metabolism is tightly regulated by hard-wired multiple layers of biological processes to achieve robust and homeostatic states given the limited resources. As a result, even the most intuitive enzyme-centric metabolic engineering endeavours through the up-/down-regulation of mul...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201637/ https://www.ncbi.nlm.nih.gov/pubmed/30359263 http://dx.doi.org/10.1186/s12934-018-1015-7 |