Discovery of proteins associated with a predefined genomic locus in living cells via dCAS9-APEX-mediated proximity labeling

Regulation of gene expression is primarily controlled by changes in the proteins that occupy their regulatory elements. Chromatin immunoprecipitation can confirm a protein’s occupancy at a genomic locus but requires specific, high-quality, IP-competent antibodies against nominated proteins, limiting...

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Detalles Bibliográficos
Autores principales: Myers, Samuel A, Wright, Jason, Peckner, Ryan, Kalish, Brian T, Zhang, Feng, Carr, Steven A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202184/
https://www.ncbi.nlm.nih.gov/pubmed/29735997
http://dx.doi.org/10.1038/s41592-018-0007-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202184/
https://www.ncbi.nlm.nih.gov/pubmed/29735997
http://dx.doi.org/10.1038/s41592-018-0007-1

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