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Discovery of proteins associated with a predefined genomic locus in living cells via dCAS9-APEX-mediated proximity labeling
Regulation of gene expression is primarily controlled by changes in the proteins that occupy their regulatory elements. Chromatin immunoprecipitation can confirm a protein’s occupancy at a genomic locus but requires specific, high-quality, IP-competent antibodies against nominated proteins, limiting...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202184/ https://www.ncbi.nlm.nih.gov/pubmed/29735997 http://dx.doi.org/10.1038/s41592-018-0007-1 |