Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

T cell antigen receptor (TCR) signaling requires the sequential activities of the kinases Lck and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, leading to the recruitment, phosphorylation, and activation of Zap70. Lck binds to and stabilizes phosho-Zap70 using its SH2 domain, and Zap70 ph...

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Detalles Bibliográficos
Autores principales: Lo, Wan-Lin, Shah, Neel H., Ahsan, Nagib, Horkova, Veronika, Stepanek, Ondrej, Salomon, Arthur R., Kuriyan, John, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202249/
https://www.ncbi.nlm.nih.gov/pubmed/29915297
http://dx.doi.org/10.1038/s41590-018-0131-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202249/
https://www.ncbi.nlm.nih.gov/pubmed/29915297
http://dx.doi.org/10.1038/s41590-018-0131-1

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