Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex

Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human papillomaviruses, E6AP targets the tumor suppressor p53 for degradation, thereby contributing to carcinogenesis. Moreover, E6 acts...

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Detalles Bibliográficos
Autores principales: Sailer, Carolin, Offensperger, Fabian, Julier, Alexandra, Kammer, Kai-Michael, Walker-Gray, Ryan, Gold, Matthew G., Scheffner, Martin, Stengel, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202321/
https://www.ncbi.nlm.nih.gov/pubmed/30361475
http://dx.doi.org/10.1038/s41467-018-06953-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202321/
https://www.ncbi.nlm.nih.gov/pubmed/30361475
http://dx.doi.org/10.1038/s41467-018-06953-0

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