Probing of G-Quadruplex Structures via Ligand-Sensitized Photochemical Reactions in (Br)U-Substituted DNA

We studied photochemical reactions of (Br)U-substituted G-quadruplex (G4) DNA substrates with two pyrene-substituted polyazamacrocyclic ligands, M-1PY and M-2PY. Both ligands bind to and stabilize G4-DNA structures without altering their folding topology, as demonstrated by FRET-melting experiments,...

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Detalles Bibliográficos
Autores principales: Saha, Abhijit, Bombard, Sophie, Granzhan, Anton, Teulade-Fichou, Marie-Paule
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202380/
https://www.ncbi.nlm.nih.gov/pubmed/30361545
http://dx.doi.org/10.1038/s41598-018-34141-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202380/
https://www.ncbi.nlm.nih.gov/pubmed/30361545
http://dx.doi.org/10.1038/s41598-018-34141-z

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