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A Partial Differential Equation Approach to Inhalation Physiologically Based Pharmacokinetic Modeling

The heterogeneous nature of the lungs and the range of processes affecting pulmonary drug disposition make prediction of inhaled drugs challenging. These predictions are critical, as the local exposure cannot be measured and current inhalation physiologically based pharmacokinetic (PBPK) models do n...

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Detalles Bibliográficos
Autores principales: Boger, Elin, Wigström, Oskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202470/
https://www.ncbi.nlm.nih.gov/pubmed/30084547
http://dx.doi.org/10.1002/psp4.12344