Cargando…

EMT induced by loss of LKB1 promotes migration and invasion of liver cancer cells through ZEB1-induced YAP signaling

Liver cancer cells often exhibit mesenchymal phenotypes, a critical phenotypic alteration of cancer cells termed the epithelial-mesenchymal transition (EMT). To examine whether liver kinase B1 (LKB1) serves a potential role in EMT in liver carcinogenesis, in the present study, it was determined that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiu, Bijun, Wei, Wei, Zhu, Jianwen, Fu, Guangshun, Lu, Dahai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202531/ https://www.ncbi.nlm.nih.gov/pubmed/30405784 http://dx.doi.org/10.3892/ol.2018.9445

Ejemplares similares

LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
por: Qu, Shuang, et al.
Publicado: (2022)

Genome‐wide cooperation of EMT transcription factor ZEB1 with YAP and AP‐1 in breast cancer
por: Feldker, Nora, et al.
Publicado: (2020)

ZEB1-induced LINC01559 expedites cell proliferation, migration and EMT process in gastric cancer through recruiting IGF2BP2 to stabilize ZEB1 expression
por: Shen, Huojian, et al.
Publicado: (2021)

LINC01413/hnRNP-K/ZEB1 Axis Accelerates Cell Proliferation and EMT in Colorectal Cancer via Inducing YAP1/TAZ1 Translocation
por: Ji, Ling, et al.
Publicado: (2019)

Cordycepin Inhibits Triple-Negative Breast Cancer Cell Migration and Invasion by Regulating EMT-TFs SLUG, TWIST1, SNAIL1, and ZEB1
por: Wei, Chunli, et al.
Publicado: (2022)

PHRF1 promotes migration and invasion by modulating ZEB1 expression
por: Lee, Jin-Yu, et al.
Publicado: (2020)

Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer
por: Kan, Jung-Yu, et al.
Publicado: (2016)

The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas
por: Sánchez-Tilló, Ester, et al.
Publicado: (2023)

ELF3 is an antagonist of oncogenic-signalling-induced expression of EMT-TF ZEB1
por: Liu, D, et al.
Publicado: (2018)

Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis
por: Xiang, Yangfeng, et al.
Publicado: (2022)

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors
por: Mock, Kerstin, et al.
Publicado: (2015)

LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer
por: Wang, Shuren, et al.
Publicado: (2019)

VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer
por: Zhang, Dan, et al.
Publicado: (2020)

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT
por: Flum, Marion, et al.
Publicado: (2022)

SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell–cell junctions
por: Vandewalle, Cindy, et al.
Publicado: (2005)

MiR-132 Suppresses the Migration and Invasion of Lung Cancer Cells via Targeting the EMT Regulator ZEB2
por: You, Jiacong, et al.
Publicado: (2014)

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia
por: Iyengar, Puneeth, et al.
Publicado: (2023)

Enhanced nuclear localization of YAP1‐2 contributes to EGF‐induced EMT in NSCLC
por: Guo, Qiang, et al.
Publicado: (2022)

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues
por: Chan, Keefe T., et al.
Publicado: (2014)

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling
por: Sheng, Weiwei, et al.
Publicado: (2020)

Yap1-2 Isoform Is the Primary Mediator in TGF-β1 Induced EMT in Pancreatic Cancer
por: Gao, Chao, et al.
Publicado: (2021)

Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT
por: Yoshimoto, Shohei, et al.
Publicado: (2019)

FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1
por: Morillo-Bernal, Jesús, et al.
Publicado: (2019)

ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC
por: Lazarova, Darina, et al.
Publicado: (2017)

Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer
por: Wu, Hua-Tao, et al.
Publicado: (2020)

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated
por: Zhou, Wei, et al.
Publicado: (2014)

PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer
por: Lian, Shixian, et al.
Publicado: (2015)

Correction to: Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling
por: Sheng, Weiwei, et al.
Publicado: (2020)

Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis
por: Mohammadi Ghahhari, Nastaran, et al.
Publicado: (2022)

LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1
por: Wang, Xinke, et al.
Publicado: (2019)

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
por: Lehmann, Waltraut, et al.
Publicado: (2016)

Loss of LKB1 Expression Decreases the Survival and Promotes Laryngeal Cancer Metastasis
por: He, Sha-sha, et al.
Publicado: (2017)

LncRNA FLVCR1-AS1 mediates miR-513/YAP1 signaling to promote cell progression, migration, invasion and EMT process in ovarian cancer
por: Yan, Huan, et al.
Publicado: (2019)

YAP modulates TGF-β1-induced simultaneous apoptosis and EMT through upregulation of the EGF receptor
por: Liu, Yi, et al.
Publicado: (2017)

Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism
por: Huang, Yuanyuan, et al.
Publicado: (2021)

Loss of Key EMT-Regulating miRNAs Highlight the Role of ZEB1 in EGFR Tyrosine Kinase Inhibitor-Resistant NSCLC
por: Gohlke, Linus, et al.
Publicado: (2023)

EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells
por: Lindner, Pablo, et al.
Publicado: (2020)

miRNA-641 inhibits the proliferation, migration, and invasion and induces apoptosis of cervical cancer cells by directly targeting ZEB1
por: Yao, Rui, et al.
Publicado: (2018)

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
por: Burk, Ulrike, et al.
Publicado: (2008)

MEK1 Inhibitor Combined with Irradiation Reduces Migration of Breast Cancer Cells Including miR-221 and ZEB1 EMT Marker Expression
por: Anastasov, Nataša, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t43ppnkg6nf8c739mj768qqns2