Development of methods for data quantitation of spiked salmon host cell DNA in protamine sulfate by qPCR

Protamine sulfate (PS) is an approximately 4 kDa cationic polypeptide derived from chum salmon used to reverse heparin-induced anticoagulation in patients. Because the presence of residual host cell salmon DNA (resDNA) in PS drug product can pose safety concerns, processing steps during PS manufactu...

Descripción completa

Detalles Bibliográficos
Autores principales: Sommers, Cynthia, Rosenzweig, Barry, Oum, Lida, Thompson, Karol, Keire, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202693/
https://www.ncbi.nlm.nih.gov/pubmed/30377650
http://dx.doi.org/10.1016/j.dib.2018.09.135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202693/
https://www.ncbi.nlm.nih.gov/pubmed/30377650
http://dx.doi.org/10.1016/j.dib.2018.09.135

Ejemplares similares