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Development of methods for data quantitation of spiked salmon host cell DNA in protamine sulfate by qPCR

Protamine sulfate (PS) is an approximately 4 kDa cationic polypeptide derived from chum salmon used to reverse heparin-induced anticoagulation in patients. Because the presence of residual host cell salmon DNA (resDNA) in PS drug product can pose safety concerns, processing steps during PS manufactu...

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Detalles Bibliográficos
Autores principales:	Sommers, Cynthia, Rosenzweig, Barry, Oum, Lida, Thompson, Karol, Keire, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202693/ https://www.ncbi.nlm.nih.gov/pubmed/30377650 http://dx.doi.org/10.1016/j.dib.2018.09.135

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