Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

BACKGROUND: Neurogenin3 (Ngn3) and neurogenic differentiation 1 (NeuroD1), two crucial transcriptional factors involved in human diabetes (OMIM: 601724) and islet development, have been previously found to directly target to the E-boxes of the insulinoma-associated 2 (Insm2) gene promoter, thereby a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Lin, Sun, Zhong Sheng, Xiang, Bingwu, Wei, Chi-ju, Wang, Yan, Sun, Kevin, Chen, Guanjie, Lan, Michael S., Carmona, Gilberto N., Notkins, Abner L., Cai, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202866/
https://www.ncbi.nlm.nih.gov/pubmed/30359270
http://dx.doi.org/10.1186/s12967-018-1665-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202866/
https://www.ncbi.nlm.nih.gov/pubmed/30359270
http://dx.doi.org/10.1186/s12967-018-1665-6

Ejemplares similares