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Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

BACKGROUND: Neurogenin3 (Ngn3) and neurogenic differentiation 1 (NeuroD1), two crucial transcriptional factors involved in human diabetes (OMIM: 601724) and islet development, have been previously found to directly target to the E-boxes of the insulinoma-associated 2 (Insm2) gene promoter, thereby a...

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Detalles Bibliográficos
Autores principales:	Wang, Lin, Sun, Zhong Sheng, Xiang, Bingwu, Wei, Chi-ju, Wang, Yan, Sun, Kevin, Chen, Guanjie, Lan, Michael S., Carmona, Gilberto N., Notkins, Abner L., Cai, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202866/ https://www.ncbi.nlm.nih.gov/pubmed/30359270 http://dx.doi.org/10.1186/s12967-018-1665-6

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