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The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ

BACKGROUND: Metabolic reprogramming occurs in the tumor microenvironment and influences the survival and function of tumor and immune cells. Interferon-γ (IFN-γ) produced by T cells up-regulates PD-L1 expression in tumors. However, reports regarding the relationship between nutrient metabolism and t...

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Detalles Bibliográficos
Autores principales: Wang, Liping, Yang, Xuecheng, Li, Dan, Liang, Zhijuan, Chen, Yuanbin, Ma, Guofeng, Wang, Yonghua, Li, Yongxin, Liang, Ye, Niu, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203092/
https://www.ncbi.nlm.nih.gov/pubmed/30425515
http://dx.doi.org/10.2147/OTT.S180505