Novel SIRT1 inhibitor 15-deoxy-Δ(12,14)-prostaglandin J(2) and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells

Clinically relevant sirtuin (SIRT) inhibitors may possess antitumor activities. A previous study indicated that 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) exhibited potent anticancer activity by SIRT1 inhibition. Therefore, the aim of the present study was to investigate whether its derivativ...

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Detalles Bibliográficos
Autores principales: Tae, In Hwan, Park, Eun Young, Dey, Prasanta, Son, Ji Yeon, Lee, Seok-Yong, Jung, Jee h., Saloni, Saloni, Kim, Mi-Hyun, Kim, Hyung Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203160/
https://www.ncbi.nlm.nih.gov/pubmed/30221742
http://dx.doi.org/10.3892/ijo.2018.4561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203160/
https://www.ncbi.nlm.nih.gov/pubmed/30221742
http://dx.doi.org/10.3892/ijo.2018.4561

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